Preparation and characteristics of BCUN- loaded lipid ultrasound contrast agent
- VernacularTitle:载卡莫司汀脂质超声造影剂制备及特性的研究
- Author:
Xuehua ZHANG
- Publication Type:Journal Article
- Keywords:
Ultrasound constrast agent;
Cammustine;
Rabbit;
Microbubble
- From:
Journal of Chongqing Medical University
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preparate BCUN-loaded lipid ultrasound contrast agent and detect its physical properties and contrast-enhancing effects.Methods:Mechanical oscillation was used to prepare BCUN-loaded lipid contrast agent.Density was detected and analyzed with microscope.Malvern determined intensity,disposition and Zeta potential.RP-HPLC detected envelopment rate.Cryodesiccated-microb ubbles were sterilized by 60Co irradiation.Following injected it through rabbit ear vein,effects of ultrasounic enhanced imaging in rabbit liver was observed.Results:The density of microbubble was(2.6~3.1)?109/ ml.The mean intensity was(1.05?0.20)?m.The mean Zeta potential was(12.93?1.84)mV.The mean nvelopment rate was(42.6?0.11)%.After injecting this microbubble,good and sustained ultrasounic enhanced images in rabbit liver were seen.Conclusions:BCUN-loaded lipid contrast agents were successfully prepared,which hopefullyprovide a new option oftargetingtreatment for the tumor.
