Study on Brain Pharmacokinetics of Tetramethylpyrazine Phosphate After Intranasal Administration
- VernacularTitle:磷酸川芎嗪大鼠鼻腔给药靶向脑部的药动学研究
- Author:
Yilin YAN
;
Yong YE
;
Liling ZHOU
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine phosphate(TMPP);
Intranasal administration;
Microdialysis;
Pharmacokinetics
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the rat brain pharmacokinetics of tetramethylpyrazine phosphate (TMPP) after intranasal administration.Methods The pharmacokinetic behavior of TMPP in rat brain was investigated after intranasal or intravenous administration (10mg?kg-1) of TMPP.Brain samples were collected by intracerebral microdialysis.The concentration of TMPP in the sample was measured by high performance liquid chromatography (HPLC).Main pharmacokinetic parameters were calculated and analyzed by Das 2.0 pharmacokinetic software.Results The results showed that two administration methods were all fitted to one compartment model.The absorption of TMPP from the nasal cavity to brain was rapid.The concentration-time curve showed a prolonged duration of TMPP concentration in the brain after intranasal administration.AUC0-∞values were (698.26?122.59)?g?min?mL-1 in intranasal group and (446.25?107.44)?g?min?mL-1 in intravenous group,and the difference was significant between the two groups (P
