Impact of the effective parts of Acanthopanax senticosus on GABA,TH and GFAP in C_(57) BL/6 mouse model of parkinson's disease
- VernacularTitle:刺五加有效部位对C_(57)BL/6小鼠PD模型GABA、TH、GFAP影响的实验研究
- Author:
Tingting YANG
;
Shumin LIU
;
Liran CUI
;
Xuewei LIU
- Publication Type:Journal Article
- Keywords:
C_(57)BL/6 mouse model of PD;
GABA;
TH;
GFAP;
the effective parts of Acanthopanax senticosus
- From:
Chinese Traditional Patent Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of effective parts of Acanthopanax senticosus on Parkinson's disease mouse model(from C_(57) BL/6 strain) concerning Gammaamino butyric acid(GABA),nigra-striatum tyrosine hydrozylase(TH) and hippocampal glial fibrillary acidic protein(GFAP). METHODS: In MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropytidine)-induced PD mouse model(accumulative dose amounted to 150 mg/kg) pole-climbing time was determined of mice after receiving effective parts of Acanthopanax senticosus for 20 d,and GARA,TH and GFAP expression were assayed simultaneously with the help of immunohistochemical method. RESULTS: Mice's pole-climbing time was measured,GABA and TH made a significant difference between treated group and control group(P
