Effect of Yangfei Huoxue Prescription on ERK1/2 and NF ?-B of Bleomycin-induced Pulmonary Fibrosis in Rats
- VernacularTitle:养肺活血方对肺纤维化大鼠细胞外信号调节激酶1/2和核因子?-B信号通路的影响
- Author:
Jiening GONG
;
Hai GUO
;
Kaifeng WEI
- Publication Type:Journal Article
- Keywords:
pulmonary fibrosis;
Yangfei Huoxue Prescription;
ERK1/2;
NF?-B;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Yangfei Huoxue Prescription on ERK1/2 and NFK-B of bleomycin-induced pulmonary fibrosis in rats. Methods All of rats were randomly divided into seven groups and were intratracheally infused with bleomycin to build the model. Sham operation group and model group were given 5‰ CMC, dexamethasone group was given dexarnethasone solution, and each treatment group was given corresponding Chinese medicine mixture. After histological process, the expression of ERK1/2 and NFK-B were examined by SABC immunohistochemical method. Results Expression of ERK1/2 and NFK-B in model group were higher than that in sham operation group (P
