Effects of Acupuncture on Expression of Neurologic Factors in Hippocampus of Depression Rats
- VernacularTitle:针刺对抑郁大鼠海马神经因子表达的影响
- Author:
Shifen XU
;
Lixing ZHUANG
;
Chunzhi TANG
- Publication Type:Journal Article
- Keywords:
DEPRESSION/acup-mox therapy;
HIPPOCAMPUS/pathology;
NEUROTROPHIC FACTOR;
NERVE GROWTH FACTOR;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of acupuncture on brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF) expression in the hippocampus of depression rats,and to explore its possible anti-depression mechanism.Methods SD rats were randomized into the normal group,model group,acupuncture group and western medicine group.Rat models of depression were established by chronic unpredictable mild stress and by isolated raising.The western medicine group received gastric gavage of fluoxetine hydrochloride(in the dose of 2 mg?kg-1?d-1),and the acupuncture group received acupuncture on acupoints of Baihui(GV20),Xinshu(BL15) and Ganshu(BL17),once per day for 21 days.After treatment,the expression of BDNF and NGF in the hippocampus of rats was detected by immunohistochemical assay.Results The number of cells with BDNF and NGF positive expression in the hippocampus of model group was decreased(P