Experimental Study on Gukang in Improving Bone Mineral Density of Rats with Osteoporosis
- VernacularTitle:中药骨康对骨质疏松模型大鼠骨密度的影响
- Author:
Jiewen HUANG
;
Jiajia QIN
;
Suping ZHANG
- Publication Type:Journal Article
- Keywords:
GUKANG/pharmacology;
OSTEOPOROSIS/TCD therapy;
BONE MINERAL DENSITY;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Chinese medicine of Gukang(GK) on bone mineral density(BMD) in osteoporosis rats.Methods Seventy-two female SD rats were randomized into 6 groups: pseudo-operation group,model group,nilestriol group(in the dose of 1mg/kg),and high-,middle-and low-dose GK groups(9.6,4.8 and 2.4 g?kg-1?d-1 respectively).Rat models of osteoporosis were induced by removal of bilateral ovaries.Three months after operation,the rats were given the corresponding medicine according the experimental design.After treatment for 3 months,in-vivo BMD as well as the in-vitro BMD in the isolated left femur and tibia was detected with dual energy X-ray bone densitometer.Results The in-vivo general BMD and lumbar BMD of the model group were decreased(P
