Effects of Angong Niuhuang Bolus on Vital Organ Injury and Mortality in Rats with Sepsis
- VernacularTitle:安宫牛黄丸对脓毒症大鼠重要器官损伤及死亡率的影响
- Author:
Dan ZHANG
;
Ping HUANG
;
Jun LI
;
Zhiyi HU
;
Yanli WANG
- Publication Type:Journal Article
- Keywords:
ANGONG NIUHUANG BOLUS/pharmacology;
SEPSIS/TCD therapy;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Angong Niuhuang Bolus(ANB) on vital organ injury and mortality in rats with sepsis.Methods SD rats were randomized into normal control group,model group,and low-,middle-and high-dose ANB groups(in the dose of 1.0,2.0 and 3.0 g?kg-1?d-1 respectively).Except that the normal control group,the rats in other groups received cecal ligation and puncture(CLP) method to induce sepsis through abdominal infection.ANB groups were given gastric gavage of ANB 0.5 hours before CLP and 6 hours after CLP.After CLP for 24 hours,the mortality was observed,serum levels of alanine aminotransferase(ALT),total bilirubin(TB) and creatinine were detected,and pulmonary myeloperoxidase(MPO) activity in all of the rats was examined.Results Serum ALT and TB levels,MAO activity and 24-hour mortality were increased in the model group(P