Effect of Kangxian Yixin Extract on collagen typeⅠand Ⅲ of mRNA in rats with dilated cardiomyopathy
- VernacularTitle:抗纤益心方对扩张型心肌病大鼠心肌Ⅰ、Ⅲ型胶原mRNA表达的影响
- Author:
Zhentao WANG
;
Lihua HAN
;
Mingjun ZHU
;
Songbo CHAI
;
Chenghao CAO
- Publication Type:Journal Article
- Keywords:
Kangxian Yixin Extract;
dilated cardiomyopathy;
ventricular remodeling;
typeⅠand type Ⅲ collagen;
immune tissuechemical method;
reverse transcription-polymerase chain reaction
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the mechanisms of Kangxian Yixin Extract(Radix Codonopsis,Radix Astragali,Poria,Rhizoma Atractylodis macrocephalae,Radix et Rhizoma Salviae miltiorrhizae,Rhizoma Chuanxiong,Flos Carthami,Radix Paeoniae rubra,Herba Lycopi,Herba Leonuri) on ventricular remodeling after dilated cardiomyopathy. METHODS: Ventricular remodeling model was induced by giving Furazolidone in wistar rats for 8 weeks and survival rats were divided into 5 groups(14 rats each group) after another 8 weeks,all the rats were killed.The effects of Kangxian Yixin Extract on typeⅠand type Ⅲ collagen gene expression were determined with SP and RT-PCR methods. RESULTS: Collagen TypeⅠand Ⅲ of model group was significantly higher than that of normal group(P0.05),while higher than that of the low dosage of group(P
