Electrophysiological and Behavioral Changes by Phosphodiesterase 4 Inhibitor in a Rat Model of Alcoholic Neuropathy.
10.3340/jkns.2012.52.1.32
- Author:
Kyoung Hee HAN
1
;
Sung Hoon KIM
;
In Cheol JEONG
;
Young Hee LEE
;
Sei Jin CHANG
;
Bit Na Ri PARK
;
Seok Won KIM
Author Information
1. Department of Obstetrics and Gynecology, Yonsei University Wonju College of Medicine, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
Alcoholic neuropathy;
Phosphodiesterase 4 inhibitor;
Rolipram
- MeSH:
Alcoholic Neuropathy;
Alcoholics;
Animals;
Burns;
Cyclic Nucleotide Phosphodiesterases, Type 4;
Ethanol;
Evoked Potentials, Somatosensory;
Humans;
Hyperalgesia;
Injections, Intraperitoneal;
Rats;
Rolipram
- From:Journal of Korean Neurosurgical Society
2012;52(1):32-36
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of the present study is to investigate the effect of rolipram, a phosphodiesterase 4 inhibitor, against alcohol-induced neuropathy in rats. METHODS: Allodynia was induced by administering 35% v/v ethanol (10 g/kg; oral gavage) to Spraue-Dawley rats for 8 weeks. Rolipram and saline (vehicle) were administered intraperitoneally. Mechanical allodynia was measured by using von Frey filaments. Somatosensory evoked potential (SEP) was proposed as complementary measure to assess the integrity of nerve pathway. RESULTS: The ethanol-induced mechanical allodynia began to manifest from 3 week, and then peaked within 1 week. Beginning from 3 week, latency significantly started to increased in control group. In rolipram treated rats, the shorter latency was sustained until 8 weeks (p<0.05). The mechanical allodynia, which began to manifest on the 3 weeks, intraperitoneal injections of rolipram sustained statistical difference until 8 weeks, the final week of the study (p<0.05). CONCLUSION: This study suggests that rolipram might alleviate mechanical allodynia induced by alcohol in rats, which clearly has clinical implication.
