Effect of Yiqi Huoxue Prescriptions on Prevention of Neointima Hyperplasia after Carotid Artery Balloon Injury in Rats
- VernacularTitle:益气活血方对高脂大鼠颈总动脉球囊损伤后血管内膜增生的影响
- Author:
Bin LIU
;
Xia HU
;
Fengchun FU
- Publication Type:Journal Article
- Keywords:
percutaneous coronary intervention;
supplementing Qi and promoting blood circulation;
balloon injury;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Yiqi Huoxue prescriptions on prevention of neointima hyperplasia after carotid artery vascular injury in rats.Methods Ninty male SD rats were randomly divided into 6 groups:the model group,the aspirin group,the low-dose Yiqi Huoxue group,the mid-dose Yiqi Huoxue group and the high-dose Yiqi Huoxue group.All of the rats were fed with hypercholesterolemic diet for 30 days,then the 2.0F balloon catheter injury was perfomed through the right femoral artery into the left common carotid artery of rats,the balloon was inflated and deflated 3 times.The rats was given drugs from 1 d before injury and to 5 d,14 d,28 d after injury.Around 6 rats from each group were euthanized by exsanguination at appropriate time point.The injuried left common carotid arteries were carefully removed and harvested for HE staining.Results The neointima hyperplasia was faint at 5 d after the operation.Morphological analysis demonstrated that there were markedly differences in the area of neointima hyperplasia at 14 d or 28 d,the average thickness of neointima hyperplasia,the surplus area of lumen/the total area of lumen between the high-dose Yiqi Huoxue group and the model group(P
