Influence of Herbs of Reinforcing Spleen to Replenishing Qi on I ?B/NF- ?B Signaling in Rats with Bronchial Asthma of Spleen Deficency
- VernacularTitle:补脾益气方药对脾虚哮喘大鼠肺组织I?B/NF-?B信号途径的影响
- Author:
Chun LIU
;
Yanjie WANG
;
Danyu ZHAO
- Publication Type:Journal Article
- Keywords:
spleen deficency;
bronchial asthma;
I ?B ?;
NF-?B;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate airway inflammation,number of eosinophils in blood and BALF,the expression of inhibitor protein ?(I ?B ?) and nuclear factor-?B(NF-?B) activity in lung of rat with spleen deficiency asthma,and the effect of herbs of reinforcing spleen to replenishing Qi.Method Thirty rats were randomly divided into three groups:control group(group A),spleen deficiency asthma group(group B),decoction group(group C).The pathological changes of lung was detected by HE staining,and the expression of I ?B ? and activity of nuclear factor ?B p65(NF-?B p65) was assessed in lung by immunohistochemistry.Results Compared with group A,the expression of I ?B ? significantly reduced(P
