Effect of Permeation Enhancers on the Percutaneous Absorption of Artesunate in Vitro
- VernacularTitle:促渗剂对青蒿琥酯贴剂体外经皮吸收的影响
- Author:
Lin QIU
;
Naijie WANG
;
Feng DU
- Publication Type:Journal Article
- Keywords:
artesunate;
transdermal delivery system;
percutaneous absorption;
penetration enhancers;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
IPA.Skin permeation was significantly enhanced by increasing the loading concentration of OA or NMP,larger IPA amount(8%) or PG amount(20%) could inhibit the permeation of artesunate.Conclusion Oleic acid was found to be the most efficient enhancer for artesunate,10% is the most effective concentration.
