The mechanism of hypoxia-induced persistent pulmonary hypertension of newborn and pulmonary vascular remodeling
10.3760/cma.j.issn.1673-4408.2010.02.001
- VernacularTitle:低氧性新生儿持续肺动脉高压与肺血管重建发生机制
- Author:
Yanping XU
;
Lizhong DU
- Publication Type:Journal Article
- Keywords:
Persistent pulmonary hypertension of newborn;
Hypoxia;
Endothelial cell;
Smooth muscle cell;
Pulmonary vascular remodeling
- From:
International Journal of Pediatrics
2010;37(2):109-111,148
- CountryChina
- Language:Chinese
-
Abstract:
Persistent pulmonary hypertension of newborn (PPHN) is a clinical syndrome,characterized by pulmonary arterial pressure elevated relative to systemic blood pressure,leading to extrapulmonary right-to-left shunting of blood across the ductus arteriosus and foramen ovale,causing severe hypoxemia.Pulmonary vascular remodeling is pathognomonic of hypoxia-induced PPHN.The regulatory mechanism and cell composition of vascular wall were dysfunction,which led to vascular wall thickened.The review focus on three aspects,such as endothelial cells,smooth muscle cells,and adventitial cells,described the relation and the possible mechanisms between hypoxia-induced PPHN and pulmonary vascular remodeling.
