Ligustrazine delay the proceeding of chronic allograft nephropathy in rat
- VernacularTitle:川芎嗪延缓大鼠慢性移植肾肾病作用及机制的研究
- Author:
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Ligustrazine;
Chronic allograft nephropathy;
Apoptosis
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the therapeutical effect of Tetramethylpyrazine on chronic allograft nephropathy of rat, reveal the relationship with CAN, then discovering mechanism of action that delaying the proceeding of CAN of rat, which provide a new way of therapy to extend survival time of transplanting kidney. Methods: We used Fisher rats as donors and Lewis rats as recipients to establish the model of CAN. 75 rats with transplanting kidney were divided into 3 groups: Ciclosporin group, TMP associating with Ciclosporin group and black group; every group for 25 rats. Renal cell apop totic index was examined by means of terminal deoxynucleotidyl transferase2mediated d-UTP nick end labeling (TUNEL). The expressions of Bcl-2 and Bax in kidney was immunohistochemically evaluated and. The kidney histology were observed by light microscope. Results:The rats of black group were died in two weeks. Ciclosporin group, appearance the histopathological changes of CAN since 4th week, it is thus evident that typical histopathological changes of CAN at 12th week. TMP associating with Ciclosporin group was later. There was significant difference(P
