Influence of mycophenolic acid on survival prolongation of renal allografts with tolerogenic dendritic cells
- VernacularTitle:霉酚酸合并致耐受树突状细胞延长小鼠心脏移植物的研究
- Author:
Feng LI
- Publication Type:Journal Article
- Keywords:
Mycophenolic acid;
Dendritic cells;
Heart transplantation
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of mycophenolic acid(MPA) on survival prolongation of heart allografts with tolerogenic dendritic cells(DCs ) in rat s. Methods:The influence of MPA on CTLA-4Ig-gene transferred donor DCs was observed in vitro morphologically and functionally. The influence of MPA on the survival time of the heart allografts was observed in a Blab/C→C57 Cervical Heterotopic Heart transplantation model with recipients treated by CTLA-4Ig-gene transferred donor DCs. Results:The maturation and aging of DC were delayed and the stimulating ability of DC to recipient splenic cells was impaired significantly with the adding of MPA . Survival time of renal allograft s in CTLA-4Ig-gene transferred DC group was prolonged significantly and further prolonged with the adding of MPA. The allografts functioned well even after 45 d postoperatively in recipient t reated with MPA preconditioned DC. Conclusion:MPA preconditioning impairs the ability of antigen presentation of CTLA-4Ig-gene transferred donor DCs and enhances it s efficacy of survival prolongation of heart allografts in mice.
