Experimental study on the influence of ultrasound-mediated microbubble on the medicine concentration in rat prostate
- VernacularTitle:超声微泡对大鼠前列腺中药物浓度的影响
- Author:
Wuran WEI
- Publication Type:Journal Article
- Keywords:
Cernilton;
Medicine concentration;
Rat;
Ultrasound;
Microbubble;
Prostate;
EA-10
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To increase the medicine concentration in rat prostate by the "sound aperture effect" and site-targeted effect of ultrasound-Mediated Microbubble in order to get better therapeutic effect. Methods: 30 1-year-old male Sprague-Dawley rats were castrated and injected estradiol benzoate for 30 days and divided into three groups randomly, model group, treatment group and ultrasound-mediated microbubble group. Model group was treated with sodium chloride, treatment group was treated with EA-10 and ultrasound-mediated microbubble group was given ultrasound-mediated microbubble and EA-10. Concentration of EA-10 in prostate was measured after the prostate was taken and homogenated. Results: Concentration of EA-10 in treatment group as higher than that of in model group(P
