Influence of dendritic cells modified with ICOS extracellular region on survival of renal allografts in rats
- VernacularTitle:ICOS胞外区基因修饰的树突状细胞对移植肾存活的影响
- Author:
Mingqi FAN
- Publication Type:Journal Article
- Keywords:
ICOS;
Dendritic cells;
Kidney transplantation
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of donor dendritic cells (DCs) modified with ICOS extracellular region on the survival of renal allografts in rats. Methods:Bone marrow derived DCs of Brown Norway(BN) rats were modified with ICOS extracellular region gene recombined adenovirus and injected into Lewis rats 24 h before BN→Lewis kidney transplantation. Survival time of renal allografts was observed and one-way mixed splenic cell reaction (MSR) of the recipients to donors and the third party rats were performed by means of MTT on the 20th postoperative day. Results:Survival time of renal allografts was prolonged significantly [comparedwith control, (23.2?3.08) d vs(8.5?1.4) d,P
