Effects of nonylphenol on the activity of AchE and ChAT in brian of filial rat
- VernacularTitle:壬基酚对仔代脑组织AchE和ChAT活性的影响
- Author:
Ning LU
- Publication Type:Journal Article
- Keywords:
Nonylphenol;
Offspring;
Brian;
Neurotoxicity
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects on the activity of acetylcholinesterase (AchE) and choline acetylase(ChAT) in filial rat’s brian and learning and memory capacity after the mother-rat is exposed to nonylphenol. Methods:At the first day of the pregnancy,the rats were divided into four groups,which were orally administered with NP at doses of 0,50,100 and 200 mg/kg,respectively,on gestational days 9～15. The offspring rats’s Brain tissues of each groups were dissected for AchE and ChAT activity assay and cognitive function was tested by Morris water maze. Result:Morris water maze test results showed the escape latency was longer in the groups of NP 200 mg/kg than in control group(P
