Optimization of Compatibility Ratio of Rhizoma Zingiberis and Pericarpium Citri Reticulatae Extracts for Counteracting Rats Myocardial Ischemia by Uniform Design
- VernacularTitle:均匀设计法优化干姜、陈皮提取物抗大鼠心肌缺血的最佳配比
- Author:
Lijuan OU
;
Xiaoping SUN
;
Qide LIU
;
Suiqing MI
;
Ningsheng WANG
- Publication Type:Journal Article
- Keywords:
Rhizoma Zingiberis extracts;
Pericarpium Citri Reticulatae extracts;
Uniform design;
Myocardial ischemia;
Optimal ratio
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effects of the extracts of Rhizoma Zingiberis and Pericarpium Citri Reticulatae on myocardial ischemia reduced by isoproterenol(ISO) in rats,and to explore their optimal ratio.Methods Acute myocardial ischemia rat model was established by continuously subcutaneous injection of large-dose.Then the content of the serum creatine kinase(CK) within 24 hours in rats were detected,and the optiaml ratio of Rhizoma Zingiberis and Pericarpium Citri Reticulatae was optimized by uniform design.Results Compared with the control group,the content of CK in the model group was significantly increased(P
