Antioxidative and antinitrosative effects of volatile oil from A.longiligulare T.L.Wu on ulcerative colitis mice
- VernacularTitle:海南砂仁挥发油对实验性溃疡性结肠炎小鼠抗氧化和抗NO自由基作用(英文)
- Author:
Jin ZHAO
;
Yi ZHU
;
Zhi DONG
;
Guobiao CHEN
;
Chun LIU
- Publication Type:Journal Article
- Keywords:
A.longiligulare T.L.Wu;
volatile oil;
ulcerative colitis;
antioxidation;
NO;
iNOS;
DSS,mouse
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate antioxidative and antinitrosative effects of volatile oil from A.longiligulare T.L.Wu on dextran sulfate sodium(DSS)-induced ulcerative colitis mice. METHODS: Balb/c mice were fed with 4% DSS solution for 7 d to induce ulcerative colitis.Using biochemical method,the activity of antioxidative enzyme SOD,MDA and NO were determined in normal,model,SASP and three mouse's groups with low,moderate and high volatile oil from A.longiligulare T.L.Wu respectively.At the same time,the activity of iNOS was also measured by immunohistopathology. RESULTS: The concentration of MDA and NO were reduced and SOD increased significantly in high-and moderate-volatile oil groups compared with those in the model group.The activity of iNOS was reduced significantly in high-and moderate-volatile oil groups compared with those in the model group.The results demonstrated that the expression of iNOS was significantly inhibited in DSSinduced ulcerative colitis mice after being treated with high or moderate-dosage volatile oil. CONCLUSION: Volatile oil from A.longiligulare T.L.Wu has antioxidative and antinitrosative effects which may be one of the mechanism for treating UC.
