Pharmacokinetic of berberine in combination of Cortex Phellodendri and Rhizoma atractrylodis in rat
- VernacularTitle:黄柏、苍术药对提取物中盐酸小檗碱在大鼠体内的药代动力学研究
- Author:
Yang ZHANG
;
Zhenqiu ZHANG
;
Zhaoshu SUN
;
Yejun HE
- Publication Type:Journal Article
- Keywords:
extracts of Huangbai and Cangshudrug-pair;
pharmacokinetic;
berberine
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To use seven parts cortex phellodendri and one part Rhizoma atractrylodis to extract mixedly,and study mouse's pharmacokinetic parameter of berberine derived from extract. METHODS: Evodiamine was taken as the marker,HPLC was used to determine berberine content in rat plasma. RESULTS: The linear range of rat's plasma sample was within 0.006 6-0.211 2 ?g/mL,RSD was little than 10%,detection limit was 0.0033 ?g/mL.The main pharmacokinetic parameters consisted of 2 h(T_max),0.183 mg/L(C_max),10.87 h(MRT_0-24),21.562?4.448(MRT_0-∞). CONCLUSION: Berberine in combination of cortex phellodendri and Rhizoma atractylodis can be quickly absorb and achieve the peak value,but metabolize slowly.
