Determination of 5 aphrodisiacs illegally adulterated into Chinese proprietary medicine by LC/MS(n) Trap
- VernacularTitle:LC/MS(n)法检测补肾壮阳类中成药和保健食品中非法添加5种性功能类化学药品
- Author:
Chang LIU
;
Jing XIA
;
Qing HU
;
Shen JI
- Publication Type:Journal Article
- Keywords:
aphrodisiac;
Chinese proprietary medicine;
liquid chromatography-mass spectrometry trap chromatography
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine 5 different aphrodisiacs,including apomorphine,yohimbine,vardenafil,sildenafil and alprostadil,adulterated into Chinese proprietary medicine by LC/MS(n),and build a laboratory library including MS(n) spectra and retention time. METHODS: ZORBAX SB C_18 column(150 mm?4.6 mm,5 ?m)was applied.The mobile phase consisted of acetonitrile and 0.5% formic acid changing by linear gradient elution,and the flow rate was 1.0 mL/min.The ion trap mass spectrometer with positive ion mode electrospray(ESI?) was applied. RESULTS: In the mass spectrum apomorphine,yohimbine,vardenafil and sildenafil showed abundant pseudomolecular ion +,and alprostadil showed abundant pseudomolecular ion -.All the MS(n) spectra showed characteristic product ion. CONCLUSION: It is proved that the method is simple,reliable and suitable to determin aphrodisiac adulterated to health food.
