Effect of Tangbi Capsules on Ultrastructure of Sciatic Nerve in Diabetic Rats
- VernacularTitle:糖痹胶囊对糖尿病大鼠坐骨神经超微结构的影响
- Author:
Hongxia CHEN
;
Haining OU
;
Youhua GUO
;
Xueliang GAO
- Publication Type:Journal Article
- Keywords:
TANGBI CAPSULES/pharmacology;
DIABETIC PERIPHERAL NEUROPATHY/TCD therapy;
SCIATIC NERVE/ultrastructure;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Tangbi Capsules(TC)on ultrastructure of sciatic nerve in diabetic rats.Methods SD diabetic rat models were induced by one-dose intraperitoneal injection of streptozotocin(50 mg/kg).Then the diabetic rats were randomized into 5 groups: model group,high-and low-dose TC groups(in the dose of 1 and 0.5 g?kg-1?d-1 respectively),mecobalamin(250 ?g?kg-1?d-1)group,and the combination group(receiving TC 0.5 g?kg-1?d-1 and mecobalamin 250 ?g?kg-1?d-1).Meanwhile,the normal control group was also set up.After treatment for 4 weeks,the changes of utrastructure of sciatic nerve in different groups were observed under electron microscope.Results The pathological changes of sciatic nerve in diabetic rats were similar with the clinical peripheral neuropathy.The protective effect on sciatic nerve in high-dose TC group was superior to that in low-dose TC group and mecobalamin group,and the combination group had the best protective effect.Conclusion TC exerts certain protective effect on diabetic peripheral neuropathy.
