Influence of Qi-strengthening,Blood-activating and Toxin-removing Therapy on Plasma and Colonic P-selectin in Ulcerative Colitis Rats
- VernacularTitle:益气活血解毒法对溃疡性结肠炎模型大鼠血浆及结肠组织P-选择素的影响
- Author:
Hejun AN
;
Xinyue WANG
;
Mei YU
;
Jing SHEN
;
Liyan XU
;
Fangbing LIN
- Publication Type:Journal Article
- Keywords:
QI-STRENGTHENING,BLOOD-ACTIVATING AND TOXIN-REMOVING THERAPY;
COLITIS/TCD therapy;
P-SELECTIN/blood;
COLON/pathology;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate influence of Qi-strengthening,blood-activating and toxin-removing therapy on plasma and colonic P-selectin in ulcerative colitis(UC) rats.Methods Trinitrobenzene sulfonic acid(TNBS) was used for the establishment of SD rat models of UC.UC rats were randomized into the model group,western medicine group(gastric gavage of suspension of Olsalazine Sodium Capsules 0.266 g?kg-1?d-1),and herbal medicine group(gastric gavage of Kuijie Fufa Recipe 20 g?kg-1?d-1).Meanwhile,a normal control group was set up.After medication for 10 and 30 days,and after drug withdrawal for 10 days,plasma P-selectin level was detected by enzyme-linked immunosorbent assay,and colonic P-selectin expression was detected by immunohistochemical assay.Results Plasma P-selectin level was increased in the model group in different time(P
