Pathogenic Mechanism Associated with Insulin Resistance and Adiponectin Abnormality in Carotid Atherosclerosis Patients Complicated with Nonalcoholic Fatty Liver Disease and Their Relationships with Traditional Chinese Medical Syndrome Types
- VernacularTitle:颈动脉粥样硬化与非酒精性脂肪肝的胰岛素抵抗、脂联素异常相关机制及与中医证型关系分析
- Author:
Yi ZHANG
;
Shanghua XU
- Publication Type:Journal Article
- Keywords:
CAROTID ATHEROSCLEROSIS/pathogenesis(TCM);
NONALCOHOLIC FATTY LIVER /pathogenesis(TCM);
INSULIN RESISTENCE;
ADIPONETIN/blood
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathogenic mechanism associated with insulin resistance(IR) and adiponetin(APN) abnormality in carotid atherosclerosis(CAS) patients complicated with nonalcoholic fatty liver disease(NAFLD),and to study their relationships with traditional Chinese medical(TCM) syndrome types.Methods Seventy-four CAS patients complicated with NAFLD(group A) and 25 CAS patients(group B) were enrolled into the study.Fasting blood glucose(FBG),fasting serum insulin(FI),and serum APN levels were measured.IR and APN were evaluated by the homeostasis assessment(HOMA) method.HOMA-IR and APN in group A were compared with those in group B,and bivariate correlation analysis was made between the two indexes in group A.The relationship of HOMA-IR and APN with TCM syndrome types was analyzed in group A.Results (1) HOMA-IR was obviously increased,and APN was obviously decreased in group A(P
