Characteristics of Hemorrhagic Peptic Ulcers in Patients Receiving Antithrombotic/Nonsteroidal Antiinflammatory Drug Therapy.
- Author:
Kazuhiko NAKAMURA
1
;
Kazuya AKAHOSHI
;
Toshiaki OCHIAI
;
Keishi KOMORI
;
Kazuhiro HARAGUCHI
;
Munehiro TANAKA
;
Norimoto NAKAMURA
;
Yoshimasa TANAKA
;
Kana KAKIGAO
;
Haruei OGINO
;
Eikichi IHARA
;
Hirotada AKIHO
;
Yasuaki MOTOMURA
;
Teppei KABEMURA
;
Naohiko HARADA
;
Yoshiharu CHIJIIWA
;
Tetsuhide ITO
;
Ryoichi TAKAYANAGI
Author Information
1. Department of Medicine and Bioregulatory Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. knakamur@intmed3.med.kyushu-u.ac.jp
- Publication Type:Original Article
- Keywords:
Peptic ulcer;
Hemorrhagic ulcer;
Antithrombotic therapy;
Anti-inflammatory agents, non-steroidal;
Endoscopic hemostasis
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
Endoscopy;
Endoscopy, Digestive System;
Hemoglobins;
Hemorrhage;
Hemostasis, Endoscopic;
Humans;
Incidence;
Medical Records;
Peptic Ulcer
- From:Gut and Liver
2012;6(4):423-426
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. METHODS: We investigated the medical records of 485 consecutive patients who underwent esophagogastroduodenoscopy and were diagnosed with hemorrhagic gastroduodenal ulcers. The patients treated with antithrombotic agents/NSAIDs were categorized as the antithrombotic therapy (AT) group (n=213). The patients who were not treated with antithrombotics/NSAIDs were categorized as the control (C) group (n=263). The clinical characteristics were compared between the groups. RESULTS: The patients in the AT group were significantly older than those in the C group (p<0.0001). The hemoglobin levels before/without transfusion were significantly lower in the AT group (8.24+/-2.41 g/dL) than in the C group (9.44+/-2.95 g/dL) (p<0.0001). After adjusting for age, the difference in the hemoglobin levels between the two groups remained significant (p=0.0334). The transfusion rates were significantly higher in the AT group than in the C group (p=0.0002). However, the outcome of endoscopic hemostasis was similar in the AT and C groups. CONCLUSIONS: Patients with hemorrhagic peptic ulcers receiving antithrombotic/NSAID therapies were exposed to a greater risk of severe bleeding that required transfusion but were still treatable by endoscopy.
