Preliminary study on self-emulsifying drug delivery system of tanshinone
- VernacularTitle:丹参酮自乳化药物传递系统的初步研究
- Author:
Xiaojun YANG
;
Xiying WEI
;
Huixian XU
- Publication Type:Journal Article
- Keywords:
tanshinone self-emulsifying drug delivery system (SEDDS);
tanshinone;
pseudo-ternary diagram;
stability
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen the formulation for tanshinone self-emulsifying drug delivery system (SEDDS) and evaluate its stability.Methods The optimal tanshinone SEDDS formulation was established through solubility experiment,emulsion examination,fully emulsified time,droplet size determination,and pseudo-ternary diagram drawing.The content and stability were evaluated by HPLC assay under the condition of illumination,high and low temperature.Results The oil phase,surfactant and co-surfactant in the optimal tanshinone SEDDS formulation were ethyl oleate,TX10,Tween 80,and isopropyl alcohol (60∶84∶21∶35).Conclusion The acquired formulation of tanshinone SEDDS is stable in the dark and room temperature.
