Effects of pioglitazone on carotid intima-media thickness in newly diagnosed type 2 diabetic patients
- VernacularTitle:吡格列酮对初诊2型糖尿病患者颈动脉内膜中层厚度的影响
- Author:
Yun HE
- Publication Type:Journal Article
- Keywords:
Pioglitazone;
Type 2 diabetes disease;
Carotid intima-media thickness;
Thiazolidinediones;
Atherosclerosis
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the change of carotid intima-media thickness(CIMT) in newly diagnosed patients with type 2 diabetic in response to pioglitazone and to analyse a possible mechanism of anti-atherosclerosis effects of pioglitazone.Method:Sixty-two newly diagnosed type 2 diabetic patients were randomly enrolled into treatment group with pioglitazone and control group.The CIMT and some relative biochemical indicators were measured.Results:After treatment with pioglitazone,the CIMT,fasting plasma glucose(FPG),hemoglobin A1c(HbA1c),fasting insulin(FINS),high sensitive C reactive protein(hsCRP) and insulin resistance index(HOMA-IR) decreased significantly(P0.05) but that the concentration of FPG and HbA1c were markedly lower than those before management(P
