Primary NK/T cell lymphoma of the testis:two cases report and review of the Iiterature
- VernacularTitle:原发睾丸NK/T细胞淋巴瘤2例报告及文献复习
- Author:
Dan LI
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Killer cell;
Natural;
T-cell;
Testis;
CD56;
EBV
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical and pathological features of primary NK/T cell lymphoma of testis and to investigate the effective diagnosis and treatment of this disease.Methods:The surgical specimens of two patients with primary NK/T cell lymphoma of the testis were observed by light microscopy,immunohistochemistry and examined by in situ hybridization for Epstein-Barr virus(EBV) RNA and the literature were reviewed.Results:The two patients respectively presented with bilateral and right-side painless testicular enlargement.The neoplastic cells were positive for CD45,CD2,CD56,cytoplasmic CD3(CD3?),CD45RO and Granzyme B,while the expressions of CD57,CD20,CD79a,CD30,CK,MPO,TdT,BCL-2 and PLAP were negative.In addition,the EBV RNA was detected in the lymphoma by in situ hybridization.Conclusion:Primary NK/T cell lymphoma of the testis is a rare entity and progressed rapidly.The expression of CD56,CD3?,cytotoxic granule associated ptoteins and EBV examination by in situ hybridization play an important role in diagnosis and differential diagnosis.
