The expression of MMP-9 in human dental pulps under orthodontic forces:an immunohistochemical study
- VernacularTitle:人牙髓中基质金属蛋白酶-9受正畸力作用影响的初步分析
- Author:
Xin LIU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Dental pulp;
Immunohistochemistry;
Pulpitis;
Orthodontics
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To Study the expressions of Matrix metalloproteinase-9(MMP-9)in human dental pulps in patients under the effects of orthodontic forces.Methods:10 orthodontic patients were selected,the orthodontic teeth to be extracted were decided before orthodontic treatments had started.One side of the orthoodontic tooth underwent routine orthodontic forces.The teeth were extracted within 1 to 7 days after orthodontic forces had been used.There were 20 teeth as under-forces group.The other side of the pre-extracted teeth did not receive any orthodontic forces.There are also 20 teeth as homologized control group.20 third molares clinically diagnosed with endodontitis and without worth of remaining were as inflamed group.Iimmunohistochemical streptavidin peroxidase method(SP method) was used.The expression of MMP-9 was analyzed by analysing images and half-quantitative analysis.Results:There was expression of MMP-9 in control,under-forces and inflamed groups.In under-forces pulpal tissues,MMP-9 was mainly expressed in odontoblasts and fibroblasts.In under-forces pulps,the expression of MMP-9 was manifestly stronger than that of controls,but weaker than that of the inflamed one.The differences among the three groups had statistical significance(P
