Expression of CD4,CD8 and receptor ? of T cell in pigmented purpuric dermatoses
- VernacularTitle:CD4、CD8和?受体在色素性紫癜性皮肤病T细胞中的表达
- Author:
Ting LIU
- Publication Type:Journal Article
- Keywords:
Pigmented purpuric dermatoses;
Mycosis fungoides;
CD4;
CD8;
TCR-?
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between PPD and MF on the basis of the surface antigen CD4,CD8 and receptor ? of T cell,so as to provide if PPD can represent a cutaneous lymphoid dyscrasia.Methods:The expression of CD4 and CD8 was measured by immunohistochemical technique in specimens obrained from lesional skin of 23 cases of PPD,20 cases of MF and skin of 20 cases of normal persons.The TCR-gamma gene rearrangement was detected with PCR.Results:15 cases of PPD have obvious migrations of lymphocytes to the epidermis.Their 5 cases and 20 cases of MF show T cell epidermotopism;18 cases of PPD,20 cases of MF and 6 cases of normal persons show a dominance of CD4+.In the dermis,the numbers of CD4+ between PPD and MF are 38.2?30.6 and 68.8?47.6(P
