Treatment hyperthyroidism in children with antithyroid drug at National Pediatric Hospital: Results and some influencing factors.
- Author:
Hoang Bich Nguyen
;
Dat Phu Nguyen
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
antithyroid
- MeSH:
Hyperthyroidism/ pathology;
therapy;
Child
- From:Journal of Medical Research
2007;55(6):104-108
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Hyperthyroidism is a disorder of thyroid function in which body tissues are exposed to excessive amount of circulating thyroid hormone. It causes the uncontrolable homeostatic. Objectives:This study aims to learn about the results of the treatment by antithyroid and some factors influencing these results in children at National Hospital for Pediatric. Subjects and method:A descriptive, cross sectional in combination with retrospective and prospective study was conducted on 51 patients with hyperthyroidism were treated by antithyroid in the National Hospital for Pediatric from May 1995 to May 2005 and with therapy duration from 12 months upward. Result: Remission rate was 58.8% (30/51) with an average follow - up period after therapy withdrawal of 2.5 \xb1 1.6 years (13 months in minimum) and the relapse rate was 41.2% (21/51) at the age over 10 years old. The antithyroid drug discontinuation, therapy duration <3 years, stress, infection were factors influencing treatment outcome. Relapse was of 90% when therapy duration was under 3 years. Goiter size at diagnosis moment was a significant determinant factor of relapse. Conclusion: Most patients reached remission. The factors affected treatment results were age, antithyroid drug discontinuation, therapy duration, stress, infection, late treatment, goiter size.
