Chronopharmacological study on anticoagulation and hemorheological effects of Jiming Powder
- VernacularTitle:鸡鸣散抗凝血作用及对血液流变学影响的时间药理学实验研究
- Author:
Jun HAN
;
Jianguo SONG
- Publication Type:Journal Article
- Keywords:
Jiming Powder;
circadian rhythm;
anticoagulation;
hemorheology
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe effects of Jiming Powder(Semen arecae,Pericarpium citri reticulatae,Fructus Chaenomelis,Fructus Evodiae,Folium Perillae,Radix Platycodonis,and Rhizoma Zingiberis recens) on anticoagulation and hemorheology and on the circadian variations in order to verify the rational practice of timing administering the drug by our ancestors. METHODS:The effect of Jiming Powder on clotting time(CT) was observed by using glass-tube method in mice. Quick test was used to determine the prothrombin time(PT) and circadian variations in rats. The experimental animal models of blood stasis syndrome were prepared by subcutaneous injection of adrenaline in combination with ice water bath for observing the effect of Jiming Powder on hemorheology in such types of animals,and the maximum rate of platelet aggregation was determined by method of Born turbidimetry. RESULTS:Jiming Powder could significantly delay CT and PT characteristic of circadian rhythm. As compared with the administration at daytime,CT and PT were greatly prolonged during the night. Besides,the hemorheological parameters were improved markedly in blood,plasma and fibrinogen viscosity,which suggested that the drug administration was more effective during the night than daytime. Also,the findings showed that Jiming Powder could prevent platelet aggregation induced by adenosine diphosphate. CONCLUSION:Jiming Powder plays a role in anticoagulation and improves the indication of hemorhelogy in the blood-stasis rats model,showing dosing time-dependent.
