Changes in the Clinical Outcomes of Variceal Bleeding in Cirrhotic Patients: A 10-Year Experience in Gangwon Province, South Korea.
- Author:
Young Don KIM
1
;
Gab Jin CHEON
;
Moon Young KIM
;
Ki Tae SUK
;
Soon Koo BAIK
;
Dong Joon KIM
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung, Korea. gi@gnah.co.kr
- Publication Type:Original Article
- Keywords:
Gastrointestinal hemorrhage;
Liver cirrhosis;
Esophageal and gastric varices;
Mortality
- MeSH:
Esophageal and Gastric Varices;
Gastrointestinal Hemorrhage;
Hemorrhage;
Humans;
Incidence;
Liver Cirrhosis;
Odds Ratio;
Peptic Ulcer;
Prevalence;
Republic of Korea;
Rupture
- From:Gut and Liver
2012;6(4):476-481
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Variceal rupture is one of the main causes of mortality in cirrhotic patients. However, there are limited data on the long-term outcomes of variceal bleeding. METHODS: We investigated the incidence and mortality of variceal bleeding at three endoscopic centers in Gangwon province during 3 periods (August 1996 to July 1997, August 2001 to July 2002, and August 2006 to July 2007). RESULTS: A total of 1,704 upper gastrointestinal (GI) bleedings occurred during the study periods. Peptic ulcers were found in 825 patients (48.5%), and variceal ruptures were found in 607 patients (35.6%). The variceal bleeding rate did not decrease in each period (26.0% vs 43.7% vs 33.9%, respectively). In the variceal bleeding group, the 6-week mortality rate steadily and significantly decreased (15.5% vs 10.8% vs 6.4%, respectively, p=0.027). In addition, the mortality rate was significantly higher in the variceal bleeding group than in the non-variceal bleeding group (10.4% vs 2.0%, p<0.001; odds ratio, 5.659; 95% confidence interval, 3.445 to 9.295). CONCLUSIONS: Variceal bleeding was still the major cause of upper GI bleedings and did not decrease in prevalence over the 10-year period in Gangwon province, South Korea. However, the mortality rate of variceal bleeding decreased significantly.
