Effect of Guipi Decoction on Serum IL-1? and Hippocampus IL-1RⅠ Expression of Depression Model Rats
- VernacularTitle:归脾汤对抑郁模型大鼠血清白细胞介素-1?和海马神经元白细胞介素-1受体Ⅰ型表达的影响
- Author:
Ying JI
;
Fei SHANG
;
Dayu SUN
- Publication Type:Journal Article
- Keywords:
depression;
Guipi Decoction;
IL-1?;
IL-1RⅠ;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Guipi Decoction on serum IL-1? and hippocampus IL-1RⅠ expression of depression model rats, and approach its mechanism of treating depression. Methods The depression model was established by received chronic unpredictable stress stimulus. Forty female Wistar rats were divided into four groups:control group, model group, saline group and Chinese medicine group. All rats were weighed and taken Open-field test on 0 and 22nd day, the serum IL-1? was detected with radio-immunity, and the expression of IL-1RⅠ was detected with immunohistochemical method. Result Compared with the control group, the weight, behavior points, serum IL-1?, expression of IL-1RⅠ of the model group and the saline group changed obviously while that in Chinese medicine group did not. Conclusion The anti-depressive mechanism of Guipi Decoction is related to maintaining the normal excretion of IL-1? and IL-1RⅠ expression from the chronic stress.
