Short and Long-Term Outcomes of Diabetes Mellitus in Patients with Autoimmune Pancreatitis after Steroid Therapy.
- Author:
Yuji MIYAMOTO
1
;
Terumi KAMISAWA
;
Taku TABATA
;
Seiichi HARA
;
Sawako KURUMA
;
Kazuro CHIBA
;
Yoshihiko INABA
;
Go KUWATA
;
Takashi FUJIWARA
;
Hideto EGASHIRA
;
Koichi KOIZUMI
;
Ryoko SEKIYA
;
Junko FUJIWARA
;
Takeo ARAKAWA
;
Kumiko MOMMA
;
Toru ASANO
Author Information
1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. kamisawa@cick.jp
- Publication Type:Original Article
- Keywords:
Autoimmune pancreatitis;
Diabetes mellitus;
Steroids
- MeSH:
Diabetes Mellitus;
Glucose;
Humans;
Insulin;
Pancreatitis;
Steroids
- From:Gut and Liver
2012;6(4):501-504
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Autoimmune pancreatitis (AIP) is frequently associated with diabetes mellitus (DM). This study evaluated the effect of steroid therapy on the course of DM in AIP. METHODS: Glucose tolerance was examined in 69 patients with AIP. DM onset was classified as either a simultaneous onset with AIP or an exacerbation of pre-existing DM. Based on the changes in the HbA1c levels and insulin dose, the responses of DM to steroids were classified as improved, no change, or worsened. RESULTS: Thirty (46%) patients were diagnosed as having DM (simultaneous onset, n=17; pre-existing, n=13). Three months after starting the steroid treatment, the DM improved in 13 (54%) of 24 DM patients. The DM improved in 55%, had no change in 36%, and worsened in 9% of the 11 simultaneous onset DM patients, and it improved in 54%, had no change in 31%, and worsened in 15% of the 13 pre-existing DM patients. At approximately 3 years after starting the steroid treatment, the DM improved in 10 (63%) of 16 patients. The pancreatic exocrine function improved in parallel with the changes in the DM in seven patients. CONCLUSIONS: Because approximately 60% of DM associated with AIP is responsive to steroids in the short- and long-terms, marked DM associated with AIP appears to be an indication for steroid therapy.
