The Effect of Intestinal Permeability and Endotoxemia on the Prognosis of Acute Pancreatitis.
- Author:
Young Yool KOH
1
;
Woo Kyu JEON
;
Yong Kyun CHO
;
Hong Joo KIM
;
Won Gil CHUNG
;
Chang Uk CHON
;
Tae Yun OH
;
Jun Ho SHIN
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. wookyu.jeon@samsung.com
- Publication Type:Original Article
- Keywords:
Acute pancreatitis;
Intestinal permeability;
Endotoxins;
Balthazar computed tomography severity index;
Cytokines
- MeSH:
Cytokines;
Endotoxemia;
Endotoxins;
Humans;
Interleukin-6;
Interleukins;
Length of Stay;
Pancreatitis;
Permeability;
Prognosis;
Tumor Necrosis Factor-alpha
- From:Gut and Liver
2012;6(4):505-511
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Early intestinal mucosal damage plays an important role in severe acute pancreatitis (AP). Previous studies have shown that intestinal permeability (IP), serum endotoxin and cytokines contribute to the early intestinal barrier dysfunction in AP. This study explored the predictive capacity of IP, endotoxemia and cytokines as prognostic indicators in AP patients. METHODS: Eighty-seven AP patients were included in the study. The patients were classified into three groups according to the Balthazar computed tomography severity index (CTSI). We compared the biochemical parameters, including IP, serum endotoxin level and cytokine level among the three groups. The associations of IP with serum endotoxin, cytokines, CTSI, and other widely used biochemical parameters and scoring systems were also examined. RESULTS: IP, serum endotoxin, interleukin (IL-6) and tumor necrosis factor (TNF)-alpha had a positive correlation with the CTSI of AP. Endotoxin, IL-6, TNF-alpha, CTSI, the Ranson/APACHE II score, the duration of hospital stay, complications and death significantly affect IP in the AP patients. CONCLUSIONS: We believe that IP with subsidiary measurements of serum endotoxin, IL-6 and TNF-alpha may be reliable markers for predicting the prognosis of AP. Further studies that can restore and preserve gut barrier function in AP patients are warranted.
