A toxicological study of Fuyuan capsule
- VernacularTitle:复元胶囊的毒理学研究
- Author:
Chanjuan LIU
- Publication Type:Journal Article
- Keywords:
Fuyuan capsule;
Acute toxicity;
Mouse;
Long-period toxicity;
Rat
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the acute toxicity and the long-period toxicity reaction of Fuyuan Capsule(FYC) to provide the reference dosage for human beings. Methods:Tests of acute oral toxicity: 40 mice (Kun Ming kind) were randomly divided into two groups,the drug test group and the control group. The maximum administration dosage(MAD) of FYC were determined by iq administration in mice. Tests of long oral toxicity:80 SD rats were randomly divided into four groups:high,middle,and low dose of FYC group and control group.FYC was continuously administered for 90 days.Rats were given drugs every day. When the experiment was finished and withdrawed for 14 days,rats were killed and the growth condition,blood cell counting and biochemical targets were measured.Histomorphologieal examination were simultaneously performed. Results:The MAD of FYC by iq administration was greater than 30g/kg in mice.In the long-period toxicity test,after administered repeatedly for 90 days,in high dose group AST,ALT and Crea increased(P
