Clinical observation of hemostatic effection of microporous polysaccharide hemispheres on residual liver after hepatectomy
- VernacularTitle:MPH对肝脏切除术后残肝断面止血效果的临床观察
- Author:
Bin XIE
- Publication Type:Journal Article
- Keywords:
Microporous polysaccharide hemispheres;
Hepatectomy;
Hemostasis;
Therapy
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of microporous polysaccharide hemispheres(MPH)in control of homostasis on residual liver after hepatectomy. Methods: 60 patients undergoing hepatectomy were randomized to four groups standard group,test group Ⅰ,test group Ⅱ,and control group. Patients in standard group(15 patients)were treated with routine surgical technique to achieve homostasis.In test group Ⅰ(15 patients)the MPH combined with absorbable haemostat were used as hemostatic agents while only the MPH was used in test group Ⅱ(15 patients). The other 15 patients were given absorbable haemostat as control group. The hemostasia time, the amount of blood transfusion during operation and three days after operations were evaluated, the other factors (ALT, Alb, biliary, PT)were also evaluated. Results: In the standard group, hemostasia time was (2.98?1.05) min; the blood transfusion amount was (400?200) ml during operations and (400?200) ml three days after operations; the amount of drainage was (350?100) ml. In the test group Ⅰ, hemostasia time was (3.10?0.85) min; the blood transfusion amount was (200?0) ml during operations and (200?100) ml three days after operations; the amount of drainage was (200?100) ml. In the test group Ⅱ, hemostasia time was (3.20?1.52) min; the blood transfusion amount was (200?200) ml during operations and (200?0) ml three days after operations; the amount of drainage was (150?100) ml, and while in control group, the corresponding results were (5.22?1.82) min, (600?200) ml, (400?200) ml, (400?150) ml, respectively. Satisfactory bleeding control was achieved in 5 patients with routline surgical technique, there was no significant diffterence among them. The incidence of hemostasis in control group (33%)was significantly lower than that in standard group(80%) and all test groups(73.3%, 66.7%, respectively). No hemostatic complications were noted in either group. Conclusion: MPH provides rapid, effective and safe hemostasis after hepatectomy, which can be applied in hepatectomy.
