Expression of ?-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis
- VernacularTitle:结肠癌?-catenin和FAK的表达与侵袭转移的关系
- Author:
Jiming WANG
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
?-catenin;
Focal adhesion kinase;
Neoplasm metastasis
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of ?-caten in and focal adhesion kinase(FAK)in colon carcinoma and to reveal their correlation with tumor clinicopathological features. Methods:The expression of ?-catenin and FAK in tumor tissue and normal tissue of 34 colon carcinoma patients were detected by immunohistochemistry and Western blot.Results:The expression of ?-catenin and FAK were detected both in tumor tissue and normal tissue,mostly in plasmalemma and endochylema.The expression of ?-catenin was significantly lower in tumor tissue than that in normal tissue(t=10.693,P
