Expression of p27~(kip1),skp2,p53 gene in colorectal adenocarcinoma and its significance
- VernacularTitle:大肠腺癌中p27~(kip1)、skp2和p53基因的表达及意义
- Author:
Haipeng SHI
- Publication Type:Journal Article
- Keywords:
Colorectal adenocarcinoma;
p27kip1;
skp2;
p53;
Gene
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of p27kip1,skp2 and p53 in colorectal carcinoma. Methods:The expression of p27kip1,skp2,p53 gene mRNA and protein in the progression of colorectal adenocarcinoma were investigated by reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemistry. Results:The mRNA expression of p27kip1 and p53 in colorectal adenocarcinoma were lower than that in normal colon tissue(P
