The Experimental Study on the relation of Centrosome Hyperamplification and P53 genetic mutation in Bladder Cancer
- VernacularTitle:膀胱移行细胞癌细胞中心体异常与p53基因突变关系的实验研究
- Author:
Lianqu WANG
- Publication Type:Journal Article
- Keywords:
Centrosome hyperamplification(CH);
Chromosome instability (CIN);
p53;
Transitional cell carcinoma of bladder(BTCC)
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To explore the relation of the abnormal condition of centrosome and p53 genetic mutation of bladder cancer cells,its effect on the onset and progress of the transitional cell carcinoma of bladder because of p53 genetic mutation. Methods: 76 transitional cell carcinoma of bladder were examined.The centrosome was stained by indirect immunofluorescence methods,and the primary antibody was monoclonal antibody against pericentrin.The p53 was stained by SP immunohistochemical methods and the primary antibody was monoclonal antibody against p53.Results: Through statistical analysis,detection of CH or p53 expression was useful in providing prognostic information in bladder cancer. There existed a positive correlated(r=0.707,P
