Expression of hypoxia inducible factor-1? in colorectal tumor:a meta-analysis of case-control trials
- VernacularTitle:结直肠肿瘤中缺氧诱导因子-1?表达的Meta分析
- Author:
Shangkun LI
- Publication Type:Journal Article
- Keywords:
Colorectal tumor;
Hypoxia-inducible factor 1 alpha;
Meta-analysis
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the studies about expression of HIF-1?in colorectal tumor with meta-analysis.Methods: Search was conducted on the following electronic databases:Chinese Bio-medicine Database,Medline,Embase to identify all the relevant case-control trials.Statistical analysis was performed with RevMan4.2 to investigate heterogeneity. The studies were combined and the publication bias was evaluated. Results: Totally 11 studies were recruited.Compared with normal tissue,colorectal cancer and colorectal adenoma showed a significantly higher expression of hif-1?(P0.05),the pooled OR and 95%CI was 2.20[0.98,4.97]. Conclusion:The expression of HIF-1? exists in the whole process of colorectal carcinoma. There is a significantly higher expression of hif-1?in colorectal cancer and colorectal adenoma than that in non-neoplasm colorectal mucosa,and no difference is found between colorectal cancer and colorectal adenoma.
