Different protective effect between tea polyphenol and esmolol on vascular endothelial cells secreting endothelin induced by hypoxia combined Ang-2
- VernacularTitle:茶多酚与艾司洛尔对缺氧联合Ang-2所致内皮细胞分泌内皮素保护作用的比较研究
- Author:
Guo MENG
- Publication Type:Journal Article
- Keywords:
Tea polyphenol;
Esmolol;
Vascular endothelial cell;
Endothelin;
Hypoxia;
Ang-2
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the protective effect of Tea polyphenol with that of esmolol on vascular endothelial cells secreting endothelin induced by hypoxia combined Ang-2. Methods: Vascular endothelial cells were divided into 4 groups that included control group,hypoxia+Ang-2 group,hypoxia+Ang-2+tea polyphenol group,hypoxia+Ang-2+esmolol group,and each group comprised eight samples. The changes of endothelin expression level were measured with radioimmunoassay at the time of 0.5 h,6 h,and 24 h. Results: ①The level of endothelin expression in hypoxia+Ang-2 group was higher significantly than that in the control group(P0.05),but there was significantly different at the time of 6 h and 24 h after hypoxia combined Ang-2(P
