Inhibitory Effect of Ethanol Extract of Cassia mimosoides Linn. on Dimethylnitrosamine- induced Hepatic Fibrosis in Rats
- VernacularTitle:铁甲草醇提取物抑制二甲基亚硝胺诱导大鼠肝纤维化的实验研究
- Author:
Wen ZHANG
;
Jida ZHANG
;
Ruliang LI
;
Chuangpeng SHEN
;
Xiang LI
;
Hengliu ZHANG
- Publication Type:Journal Article
- Keywords:
Ethanol extract of Cassia mimosoides Linn. (Leguminosae);
Hepatic fibrosis;
Dimethylnitrosamine;
Rats
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the inhibitory effect of ethanol extract of Cassia mimosoides Linn. (EE-CML) on dimethylnitrosamine-induced hepatic fibrosis in rats and to explore its therapeutic mechanism. Methods Sixty male SD rats were equally divided into 6 groups: normal group, model group, high-, middle-and low-dose EE-CML groups (at the doses of 12.6 g/kg, 4.2 g/kg, and 1.4 g/kg respectively) and colchicine (0.2 mg/kg). Intervention treatment with EE-CML by gastric gavage was carried out in the rats with hepatic fibrosis which was induced by dimethylnitrosamine simultaneously and their effects were compared with the group treated with colchicine. The model group and the normal group were given the same volume of saline once a day. Four weeks after treatment, hepatic function, levels of serum hyaluronic acid (HA), serum laminin (LN), serum aminoterminal propeptide of type III procollagen (PCIII), hepatic hydroxyproline (Hyp), and histopathological changes in rats were assayed and examined. Results Compared with those in the model group, in the differences of serum alanine aminotransferase (ALT) level in three EE-CML groups and serum aspartate aminotransferase (AST) level in high dose EE-CML group were statistically significant (P
