Influence of Langchuang Ⅱ on Th1/Th2 Cytokines of MRL/lpr Lupus Mice
- VernacularTitle:狼疮Ⅱ号对缺乏淋巴增殖基因狼疮鼠Th1/Th2细胞因子谱的影响
- Author:
Yuansheng WU
;
Jie OUYANG
;
Guowei XUAN
;
Dehong LIANG
- Publication Type:Journal Article
- Keywords:
LANGCHUANG Ⅱ/ pharmacology;
SYSTEMIC LUPUS ERYTHEMATOSUS/TCD therapy;
CYTOKINES;
DISEASE MODLES,ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of Langchuang Ⅱ,a Chinese medicinal compound formula,on Th1/TH2cytokines of MRL/lpr lupus mice.Methods Forty MRL/lpr mice with spontaneous systemic lupus erythematosus(SLE) were randomized into blank control group,LangchuangⅡgroup(in the dose of 20 g?kg-1?d-1),prednisone group(in the dose of 6 mg?kg-1?d-1),and the combination group(LangchuangⅡand prednisone).After medication for 8 continuous weeks,Flowcytomix technology was used for the detection of different kinds of serum Th1/Th2 cytokines.Results Compared with the blank control group,serum granulocyte-macrophage colony-forming unit(GM-CSF) level was decreased in the combination group(P0.05);IL-4,IL-5 and IL-10 were all decreaed in the medication groups,and the decrease of IL-10 was obvious in the combination group(P
