Protective Effect of Weishu Powder on Hepatic Injury Induced by Pentachloronitrobenzene
- VernacularTitle:胃舒散对五氯硝基苯致肝损伤的保护作用
- Author:
Xukai LIN
;
Yipeng ZHANG
;
Senyuan XU
- Publication Type:Journal Article
- Keywords:
WEISHU POWDER/pharmacology;
HEPATIC INJURY/TCD therapy;
LIVER/pathology;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Weishu Powder(WP) on hepatic injury induced by pentachloronitrobenzene(PCNB).Methods SD rats were randomized into 4 groups: normal group,model group,high-dosage WP group(in the dose of 2.50 g?kg-1 ?d-1) and low-dosage WP group(in the dose of 1.25 g?kg-1 ?d-1).Except the normal group,the other three groups received gastric gavage of PCNB 400 mg?kg-1 ?d-1 for 15 continuous days.After treatment,hepatic index was assayed,serum glutamic-oxalacetic transaminase(GOT) and alkaline phosphatase(ALP) levels and hepatic malondialdehyde(MDA) content were detected,and hepatic pathological examination was also carried out.Results Hepatic index,serum GOT and ALP levels,and hepatic MDA content were increased(P
