Effects of Yougui Wan on Thyroid Hormone and Cyclic Nucleotides Levels in Rats with Spleen-kidney Deficiency Syndrome
- VernacularTitle:右归丸对脾肾两虚证大鼠甲状腺激素及环核苷酸水平的影响
- Author:
Jinyan CHEN
;
Lifeng WANG
;
Hui ZHAO
;
Zhiqing LI
;
Zhixi CHEN
- Publication Type:Journal Article
- Keywords:
YOUGUI WAN/pharmacology;
SPLEEN-KIDNEY DEFICINECY SYNDROME/TCD therapy;
THYROID HORMONES;
CYCLIC NUCLEOTIDES;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The changes of thyroid hormone and cyclic nucleotides levels in rats with spleen-kidney deficiency syndrome were observed to evaluate the preventive and therapeutic effect of Yougui Wan(YW) for spleen-kidney deficiency syndrome,and to explore the relationship between the spleen and the kidney at microscopic level.Methods Male SD rats were randomly divided into normal control group,model group,and YW group.Rat models of spleen-kidney deficiency syndrome were established by gavage firstly with rhubarb(4g for each rat) decoction and then with hydrocortisone(25 mg?kg-1?d-1,im).The model group and YW group were treated with distilled water and YW(5.8 g?kg-1?d-1) respectively.The general status of rats was observed,and the plasma cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate(cGMP) levels as well as serum thyroid hormones(T3,T4 and rT3) and thyroid-stimulating hormone(TSH) contents were determined in all rats by radioimmunoassay(RIA).Results Compared with the normal control group,the serum contents of T3,T4,rT3 were decreased significantly(P
