Pharmacokinetics of Qingfengteng cataplasma transdermal delivery by electroporation
- VernacularTitle:青风藤电离巴布剂电致孔透皮给药的药动学研究
- Author:
Baohua HAO
;
Yanling WANG
;
Weize LI
;
Fan LI
;
Sen LIU
;
Shujun DU
;
Binbin TANG
- Publication Type:Journal Article
- Keywords:
Qingfengteng cataplasma transdermal deliver;
sinomenine;
electroporation;
transdermal drug delivery;
pharmacokinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects on electroporation of Qingfengteng cataplasma transdermal absorption and describe the characteristics of animal pharmacokinetics of it.Methods Two-chamber diffusion cell was used and the plasma drug concentration was determined by HPLC.The application of AIC theory to analysis of the compartmentally based model of sinomenine transdermal delivery by electroporation.Results The Cmax,Ka,and AUC0→∞ of electroporation was larger than those of passive diffusion;t1/2(Ka)and tmax of electroporation were reduced compared with passive diffusion.The drug concentration-curve equation were C=2.884?(e-0.056 t-e-0.232 t)and C=2.512?(e-0.058 t-e-0.149 t)for electroporation and passive diffusion,respectively.Conclusion The change of in vivo drug concentration of Qingfengteng calaplasma transdermal absorption by electroporation could be analized in accordance with mammillary one-compartment open model.The etrectroporation technology could sharply enhance the bioavalibility compared with the passive diffusion.
