Pathologic features of injury in ~(60)Co ?-radiation-induced diffuse cortical dysplasia in rats
- VernacularTitle:~(60)Co?射线诱导的弥漫性皮质发育不良模型鼠脑组织病理特征观察
- Author:
Chunyang LUO
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Corticaldysplasia;
Animalmode;
Hippocampus;
Mossyfiber;
Pathology
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish neonatal ?-ray irradiated injury model of diffuse cortical dysplasias(DCD)in rats to observe the features of pathology,and discuss the mechamism of pathology and epileprogenesis in this model.Methods:?-ray-induced model of DCD was established in rat.We observed the cerebral cortex change with naked eyes and under a light microscope,and assessed the hippocampal mossy fiber sprouting after HE staining,Nissl staining and Timm's histochemical method.The comparisons between every two groups were performed with Nemenyi test.Results:The rats had seizure by chance,but most of these rats displayed more active action,exiting and so on.EEG showed frequent spontaneous sharp waves,or spikes from the frontal or the hippocampal neocortical structures.Neonatal ?-ray irradiated injury could result in DCDs in cerebral cortex and mossy fiber sprouting in hippocampi CA3 area bilaterally(nonparametric Kruskal-Wallis H test and Nemenyi test,P
